Mark Kaye, DC, discusses gut health: The Gut, its Microbiota and Leaky Gut

There are over 1000 species of bacteria in the human body and it plays a major role in our health.

In the Human Microbiome Project, over 1000 microbes from cultured and uncultured bacteria that have been previously isolated from the human body, plus several non-bacterial microbes, will be sequenced. Combined with existing and other planned efforts, the total reference collection could reach 3000 genomes. There are 10 trillion microbes in the human gut microbiota. Microbes can be found in low numbers in the stomach, and higher numbers in the lower small intestine and colon. Microbiota colonization begins at birth, develops rapidly over the first year of life and continues to evolve in response to host and environmental cues throughout life.

The gut microbiota carries out many important functions, such as the production of vitamins, amino acid biosynthesis, and fermentation of non-digestible substrates, from a metabolic perspective. It also serves a variety of protective functions for the immune system, as well as structural and histological functions, specific to “leaky gut.”

Dr. Mark Kaye discusses these facts and others in this presentation.

The presentation offers important information on the development of the condition known as “leaky gut.” Leaky gut results in the access of bacterial particles, food antigens, and other lumenal content usually excluded from the body and it has been associated with several chronic conditions, including food allergy, celiac disease, inflammatory bowel disease, irritable bowel syndrome, heart failure, and others.

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