This paper is entitled, “Supplementation with Specialized Pro-Resolving Mediators Reduces Inflammatory Biomarkers and Improves Reported Clinical Symptomology in Subjects with Chronic Inflammatory Conditions: Results from a Multi-Center Open-Case Series”

The most important messages include the following:

  • Inflammation has 2 phases: initiation and resolution. Many chronic health issues are linked to unresolved inflammation
  • Specialized pro-resolving mediators (SPMs) are endogenous molecules essential for resolution of inflammation but may not be produced in required levels in certain condition
  • Multi-center case study assessed effects of a proprietary SPM supplement (LM-O3) on inflammatory biomarkers in 34 men and women (21-75 y/o) with conditions indicating raised inflammatory tone
  • Results showed a 43% reduction in high-sensitivity Creactive protein (hs-CRP) at 4 weeks with concurrent reduction in prostaglandin E2 (PGE2)
  • At 8 weeks, hs-CRP remained reduced, and PGE2 was reduced to within normal range
  • Functional measurements including reported measures of pain as well as quality of life indicated continued improvement at 4 and 8 weeks
  • Adverse events were minimal and managed without incident.

Inflammation complicates the management of many conditions such as obesity, metabolic syndrome, cardiovascular disease and diabetes. The inability to resolve both acute and chronic inflammation leads to progression and often complications of the disease state later on. Thus, improved management of an elevated inflammatory response is an important objective in patient care. This single-arm, practice-based observation study provides preliminary evidence that direct treatment with SPMs represents a potential novel approach in promoting inflammation resolution.

Download PDF

Share this:

Resources from our research partners and collaborations

Sign up for the MHICN Newsletter

Your Weekly Nutrition Bulletin features the latest content on topics spanning our therapeutic platforms from MHICN research staff and clinical partners. Receive videos, clinical modules, research reviews and more by email each week. Sign up here or view previous weeks' newsletters.

Subscribe View Newsletter Archives

Continuing Education

MHICN has partnered with leaders in preventive medicine, integrative medicine, and medical education to provide cutting-edge education for providers of all backgrounds with an interest in functional and lifestyle medicine. We are excited to share these free educational modules featuring podcasts, videos, and print articles.

Learn More