Clinical Overview of SPMs and Application to Patient Care – Robert G. Martindale, MD, PhD, Oregon Health & Science University, Portland, Oregon

Clinical Overview of SPMs and Application to Patient Care – Robert G. Martindale, MD, PhD, Oregon Health & Science University, Portland, Oregon

Presented at ASPEN CNW 2016 in Austin, Texas on January 18, 2016

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Dr. Robert Martindale proposes that we have been so lost in trying to prevent inflammation that we have forgotten about the resolution of inflammation.

Resolution is an active process. Anti-inflammation is not equivalent to Pro-Resolution. SPMs are lipid compounds Isolated in many human tissues during inflammation.

1) Chemically synthesized in lab and in vivo

2) Injected into humans at physiologic doses

3) Inflammation resolves faster – mimics natural healing

4) Prevents transition to chronic inflammation

5) Increases bacterial and viral killing, decreases need antibiotics

6) In some tissues stimulates “regeneration”

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