Small intestinal bacterial overgrowth (SIBO) is defined as an increase in the concentration of bacteria of more than 100,000 colony-forming units per mL in the small intestine.  The prevalence of SIBO with patients with Irritable Bowel Syndrome (IBS) is 56% and is thought to be almost as high in many other disorders of the digestive tract.  SIBO has become a significant problem in clinical practices leading to malabsorption and malnutrition simulating celiac disease to mild symptoms similar to IBS – all indicative of a disruption of natural protective mechanisms of the gut.  These factors predispose the gut toward dysbiosis.

While most accepted treatment regimens for SIBO include antibiotics, it is also accepted that the response to these regimens are variable and inconsistent.  Recently, a number of nutritional and natural remedies have been demonstrated to provide effective management of SIBO.  A recent study from Johns Hopkins University in Baltimore revealed that herbal remedies such as Candibactin AR and BR provide effective SIBO rescue therapy for selected non-responders to antibiotics.  A more recent study at the Cleveland Clinic demonstrated that the use of selected probiotics, with bactericin production, can also result in reduction of SIBO – all showing promise that natural, nutritional based, therapeutic approaches can be very effective in addressing the symptoms of SIBO.

Additionally, new high quality carbohydrate sources including 2’FL (2-fucosylactose) can help re-establish the microflora and microbiome.  By serving as a preferential source of energy, these selected carbohydrates help return the small intestine to normal functional capacity while also reducing the number of negative pathogens in the gut – thus addressing the issues of dysbiosis and potential complications associated with SIBO.

This growing clinical issue of SIBO will be the focus of a number of new reports and studies available on MHICN in the coming months and we invite you to visit for more insights and clinically relevant results on this health concern.

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